1. Check the error log for the MySQL 133 instance:

$ sudo tail -f /var/log/mysql/error.log

2. Check the MySQL configuration file for any misconfigurations:

$ sudo cat /etc/mysql/my.cnf

3. Check the system resources to ensure that the MySQL instance is not running out of memory or disk space:

$ free -m
$ df -h

4. Check the MySQL process list to ensure that there are no long-running queries that are causing the MySQL instance to become unresponsive:

$ mysql -u root -p
mysql> SHOW FULL PROCESSLIST;

5. Check the MySQL replication status to ensure that the MySQL instance is not lagging behind the master:

$ mysql -u root -p
mysql> SHOW SLAVE STATUS\G;

6. Restart the MySQL instance to ensure that any misconfigurations or long-running queries are cleared:

$ sudo service mysql restart

7. Use an automated database observability tool to monitor and fix the MySQL 133 instance. Automated database observability tools can provide real-time insights into the performance and health of the MySQL instance, allowing for quick and easy diagnosis and resolution of any issues that may arise. Additionally, these tools can provide alerts when certain thresholds are exceeded, allowing for proactive monitoring and resolution of any potential issues.